CMA 11 Microdialysis Probes for Discrete Areas of CNS
CMA 11 Microdialysis Probes for Discrete Areas of CNS

CMA 11 Microdialysis Probes

NEW! CMA 11 PROBES FOR LARGE MOLECULES!

Ideal for discrete areas in the CNS due to its greater spatial resolution and reduced size. Causes less tissue damage than other probe types.

  • Small diameter
  • High spatial resolution
  • Causes minimal tissue damage
  • Low internal volume
  • Membrane lengths: 1, 2, 3 or 4 mm
  • Membrane diameter: 0.24 mm (6 kDa), 0.26 mm (55 kDa) or 0.28 mm (500 kDa or 2 MDa)
  • Available metal free or β-irradiated

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The CMA 11 Microdialysis Probe is ideal for discrete areas in the CNS due to its greater spatial resolution and reduced size. It causes less tissue damage than other probe types due to its small diameter.

The CMA 11 6 kDa probe has a cuprophane membrane with an outside diameter of 0.24 mm. The outer steel shaft diameter is 0.38 mm. The inner cannula is constructed of fused silica coated with polyimid. The inlet/outlet capillaries are mounted in a white plastic body matched to the size of a corresponding guide cannula.

New CMA 11 microdialysis probe are now available with a 55 kDa cut-off and 0.26 mm outer diameter (more details in the Specifications section).

New CMA 11 microdialysis probe for large molecules are also now available with 500 kDa and 2 MDa cut-off, 0.28 mm outer diameter and 14 mm shaft length (more details in the Specifications section).

Once implanted, the probe sits tightly in the guide cannula´s capsule without the need for screwing or cementing. FEP tubing is connected to the probe using tubing adaptors.

Standard part numbers are available for metal free or β-irradiated CMA 11 6kDa probes.

For metal free or β-irradiated CMA 11 55 kDa, 500kDa and 2MDa probes, please make your request using the CMA Custom Probe Form and send it to the Technical Support Team who will contact you promptly.

CMA 11 Microdialysis Probes are guaranteed for single use.

 

Ordering Information

Product Name Item #
CMA 11 6 kDa Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8309581
CMA 11 6 kDa Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8309582
CMA 11 6 kDa Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8309583
CMA 11 6 kDa Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8309584
CMA 11 6 kDa Metal Free Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8011081
CMA 11 6 kDa Metal Free Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8011082
CMA 11 6 kDa Metal Free Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8011083
CMA 11 6 kDa Metal Free Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8011084
CMA 11 6 kDa β-Irradiated Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8011001
CMA 11 6 kDa β-Irradiated Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8011002
CMA 11 6 kDa β-Irradiated Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8011003
CMA 11 6 kDa β-Irradiated Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8011004
CMA 11 55 kDa Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8012511
CMA 11 55 kDa Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8012512
CMA 11 55 kDa Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8012513
CMA 11 55 kDa Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8012514
CMA 11 500 kDa Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8012521
CMA 11 500 kDa Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8012522
CMA 11 500 kDa Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8012523
CMA 11 500 kDa Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8012524
CMA 11 2 MDa Microdialysis Probe, 1 mm membrane length, pkg. of 3 CMA8012525
CMA 11 2 MDa Microdialysis Probe, 2 mm membrane length, pkg. of 3 CMA8012526
CMA 11 2 MDa Microdialysis Probe, 3 mm membrane length, pkg. of 3 CMA8012527
CMA 11 2 MDa Microdialysis Probe, 4 mm membrane length, pkg. of 3 CMA8012528

 

Downloads

CMA 11 6 kDa User’s Manual
CMA 11 55 kDa User’s Manual
CMA 11 500 kDa & 2mDa User’s Manual
2016 CMA Microdialysis Catalog
CMA Microdialysis Probes Catalog

 

Journal Articles

Selected Recent Publications

Devroye, C. et al., 2017. Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin2B receptor blockade: Involvement of medial prefrontal cortex serotonin1A receptors. Neuropharmacology, 119, pp.91–99.

Zhang, C. et al., 2017. Reduced GABAergic transmission in the ventrobasal thalamus contributes to thermal hyperalgesia in chronic inflammatory pain. Scientific Reports, 7. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288727/.

Kim, M. et al., 2017. Changes in dopamine, serotonin and their metabolites in brain microdialysates from rats following exposure to new psychoactive drugs. Forensic Toxicology, 35(1), pp.66–76.

Jin, W. et al., 2017. Acupuncture reduces relapse to cocaine-seeking behavior via activation of GABA neurons in the ventral tegmental area. Addiction Biology, p.n/a-n/a.

Dupuis, A. et al., 2017. Increasing spinal 5-HT2A receptor responsiveness mediates anti-allodynic effect and potentiates fluoxetine efficacy in neuropathic rats. Evidence for GABA release. Pharmacological Research, 118, pp.93–103.

Shadgan, B. et al., 2017. Optical monitoring of spinal cord hemodynamics, a feasibility study. In p. 100720T– 100720T–9. Available at: http://dx.doi.org/10.1117/12.2248776.

Cao, F., Zhang, L. & Tian, Y., 2016. A novel N-doped carbon nanotube fiber for selective and reliable electrochemical determination of ascorbic acid in rat brain microdialysates. Journal of Electroanalytical Chemistry, 781, pp.278–283.

Herrera, A. et al., 2016. Aminochrome induces dopaminergic neuronal dysfunction: a new animal model for Parkinson’s disease. Cellular and Molecular Life Sciences, 73(18), pp.3583–3597.

Kim, M. et al., 2016. Silica stationary phase-based on-line sample enrichment coupled with LC-MS/MS for the quantification of dopamine, serotonin and their metabolites in rat brain microdialysates. Analytica Chimica Acta, 923, pp.55–65.

Schober, A. et al., 2016. Microdialysis Assessment of Cerebral Perfusion during Cardiac Arrest, Extracorporeal Life Support and Cardiopulmonary Resuscitation in Rats– A Pilot Trial. PLOS ONE, 11(5), p.e0155303.

SKU: CMA 11 Category: Tags: , , , ,
Probe Name CMA 11 6 kDa CMA 11 55 kDa CMA 11 500 kDa, 2 MDa
Membrane Length 1, 2, 3 and 4 mm 1, 2, 3 and 4 mm 1, 2, 3 and 4 mm
Membrane OD 0.24 mm 0.26 mm 0.28 mm
Membrane Material Cuprophane Polyethersulfone (PES) Polyethersulfone (PES)
Molecular Weight Cut-Off 6 kD 55 kD 500 kD, 2 MDa
Shaft Diameter 0.40 mm 0.40 mm 0.40 mm
Shaft Length 14 mm 14 mm 14 mm
Inlet Volume 0.1 µL 0.1 µL 0.1 µL
Outlet Volume 1.0 µL 1.0 µL 1.0 µL